~ AlphaMD You've dialed in your TRT protocol, hit the gym religiously, cleaned up your diet, yet you still feel flat, foggy, and frustrated
While it's not yet FDA-approved, it's widely used in clinical and wellness settings under medical supervision
Human clinical data in this area remain more limited but are broadly consistent with the mechanistic findings observed in animal research
Begin with a small dose of new supplements and foods
39,58 For example, in a study, researchers indicated that TMAO mediated the inhibition of sirtuin 1 (SIRT1) expression, then activated the p53/p21/Rb pathway, leading to increased p53, p53 acetylation, and p21 acetylation, and reduces CDK2, cyclinE1, and Rb phosphorylation, thus resulting in endothelial cell senescence and arterial aging, which may induce cardiovascular diseases such as arrhythmia